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Article

Genotypic and phenotypic analyses of hepatitis C virus variants observed in clinical studies of VX-222, a nonnucleoside NS5B polymerase inhibitor.

Antimicrobial agents and chemotherapy - 1 Sept 2014

Jiang Min, Zhang Eileen Z, Ardzinski Andrzej, Tigges Ann, Davis Andrew, Sullivan James C, Nelson Michelle, Spanks Joan, Dorrian Jennifer, Nicolas Olivier, Bartels Doug J, Rao B Govinda, Rijnbrand Rene, Kieffer Tara L

Abstract excerpt

VX-222, a thiophene-2-carboxylic acid derivative, is a selective nonnucleoside inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. In phase 1 and 2 clinical studies, VX-222 demonstrated effective antiviral efficacy, with substantial reductions in plasma HCV RNA in patients chronically infected with genotype 1 HCV. To characterize the potential for selection of VX-222-resistant variants in...

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Identifiers

PMID: 24982088
DOI: 10.1128/AAC.03052-14
PMCID: PMC4135882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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