Article
Molecular modeling and residue interaction network studies on the mechanism of binding and resistance of the HCV NS5B polymerase mutants to VX-222 and ANA598.
Antiviral research - 1 Apr 2014
Xue Weiwei, Jiao Pingzu, Liu Huanxiang, Yao Xiaojun
Abstract excerpt
Hepatitis C virus (HCV) NS5B protein is an RNA-dependent RNA polymerase (RdRp) with essential functions in viral genome replication and represents a promising therapeutic target to develop direct-acting antivirals (DAAs). Multiple nonnucleoside inhibitors (NNIs) binding sites have been identified within the polymerase. VX-222 and ANA598 are two NNIs targeting thumb II site and palm I site of HCV NS5B polymerase,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.