Article
Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo.
Journal of thrombosis and haemostasis : JTH - 1 May 2014
Sundaram J, Keshava S, Gopalakrishnan R, Esmon C T, Pendurthi U R, Rao L V M
Abstract excerpt
BACKGROUND: Recent studies have shown that factor VIIa binds to endothelial cell protein C receptor(EPCR), a cellular receptor for protein C and activated protein C. At present, the physiologic significance of FVIIa interaction with EPCR in vivo remains unclear. OBJECTIVE: To investigate whether...
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