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Article

Polymorphisms in CYP2D6 have a greater effect on variability of risperidone pharmacokinetics than gender.

Basic & clinical pharmacology & toxicology - 1 Feb 2015

Cabaleiro Teresa, Ochoa Dolores, Román Manuel, Moreno Isabel, López-Rodríguez Rosario, Novalbos Jesús, Abad-Santos Francisco

Abstract excerpt

Within-subject coefficient of variation (CVw ) plays a decisive role in the determination of sample size in bioequivalence clinical trials. Highly variable drugs may require the participation of a large number of subjects. The aim of this study was to investigate whether gender and polymorphisms in CYP2D6 affect the CVw of risperidone. Two single-dose, two-period crossover studies of risperidone (n = 70) were...

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Identifiers

PMID: 24975366
DOI: 10.1111/bcpt.12286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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