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Article

Atrial fibrillation-linked germline GJA5/connexin40 mutants showed an increased hemichannel function.

PloS one - 1 Jan 2014

Sun Yiguo, Hills Matthew D, Ye Willy G, Tong Xiaoling, Bai Donglin

Abstract excerpt

Mutations in GJA5 encoding the gap junction protein connexin40 (Cx40) have been linked to lone atrial fibrillation. Some of these mutants result in impaired gap junction function due to either abnormal connexin localization or impaired gap junction channels, which may play a role in promoting atrial fibrillation. However, the effects of the atrial fibrillation-linked Cx40 mutants on hemichannel function have not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24733048
DOI: 10.1371/journal.pone.0095125
PMCID: PMC3986259

Genes

GJA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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