Article
Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations.
Blood - 28 Aug 2014
Micol Jean-Baptiste, Duployez Nicolas, Boissel Nicolas, Petit Arnaud, Geffroy Sandrine, Nibourel Olivier, Lacombe Catherine, Lapillonne Helene, Etancelin Pascaline, Figeac Martin, Renneville Aline, Castaigne Sylvie, Leverger Guy, Ifrah Norbert, Dombret Hervé, Preudhomme Claude, Abdel-Wahab Omar, Jourdan Eric
Abstract excerpt
Acute myeloid leukemia (AML) with t(8;21) (q22;q22) is considered to have favorable risk; however, nearly half of t(8;21) patients are not cured, and recent studies have highlighted remarkable genetic heterogeneity in this subset of AML. Here we identify somatic mutations in additional sex combs-like 2 (ASXL2) in 22.7% (25/110) of patients with t(8;21), but not in patients with inv(16)/t(16;16) (0/60) or...
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