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Article

Platelet-derived Growth Factor Primes Cancer-associated Fibroblasts for Apoptosis

28 Jun 2014

Abstract excerpt

Desmoplastic malignancies such as cholangiocarcinoma (CCA) are characterized by a dense stroma containing an abundance of myofibroblasts termed cancer-associated fibroblasts (CAF). The CAF phenotype represents an "activated state" in which cells are primed for cell death triggered by BH3 mimetics. Accordingly, this primed state may be therapeutically exploited. To elucidate the mechanisms underlying this poorly...

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PMID: 24973208
DOI: 10.1074/jbc.m114.563064

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