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A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy

27 Jun 2014

Abstract excerpt

A compact marker/suicide gene that utilizes established clinical-grade reagents and pharmaceuticals would be of considerable practical utility to T-cell cancer gene therapy. Marker genes enable measurement of transduction and allow selection of transduced cells, whereas suicide genes allow selective deletion of administered T cells in the face of toxicity. We have created a highly compact marker/suicide gene for...

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PMID: 24970931
DOI: 10.1182/blood-2014-01-545020

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