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Article

Methylation pattern of H19 exon 1 is closely related to preeclampsia and trophoblast abnormalities

23 Jun 2014

Abstract excerpt

Preeclampsia (PE) is a pregnancy-induced disorder characterized by the overproliferation of trophoblasts. Hydatidiform moles, which are associated with a high risk of developing PE, are characterized by the excessive proliferation of trophoblastic tissue. H19 is highly expressed in placental tissue; however, its biological function remains unclear. A fundamental modification of the H19 gene is DNA methylation,...

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Share to Gestational Trophoblastic Disease Studies
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PMID: 24969494
DOI: 10.3892/ijmm.2014.1816

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