Article
Significant shared heritability underlies suicide attempt and clinically predicted probability of attempting suicide.
Molecular psychiatry - 1 Oct 2020
Ruderfer Douglas M, Walsh Colin G, Aguirre Matthew W, Tanigawa Yosuke, Ribeiro Jessica D, Franklin Joseph C, Rivas Manuel A
Abstract excerpt
Suicide accounts for nearly 800,000 deaths per year worldwide with rates of both deaths and attempts rising. Family studies have estimated substantial heritability of suicidal behavior; however, collecting the sample sizes necessary for successful genetic studies has remained a challenge. We utilized two different approaches in independent datasets to characterize the contribution of common genetic variation to...
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