Article
Beyond the chromosome: the prevalence of unique extra-chromosomal bacteriophages with integrated virulence genes in pathogenic Staphylococcus aureus.
PloS one - 1 Jan 2014
Utter Bryan, Deutsch Douglas R, Schuch Raymond, Winer Benjamin Y, Verratti Kathleen, Bishop-Lilly Kim, Sozhamannan Shanmuga, Fischetti Vincent A
Abstract excerpt
In Staphylococcus aureus, the disease impact of chromosomally integrated prophages on virulence is well described. However, the existence of extra-chromosomal prophages, both plasmidial and episomal, remains obscure. Despite the recent explosion in bacterial and bacteriophage genomic sequencing, studies have failed to specifically focus on extra-chromosomal elements. We selectively enriched and sequenced...
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