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Transition of <i>Staphylococcus aureus</i> tetracycline resistance plasmid pT181 from independent multicopy replicon to predominantly integrated chromosomal element over 65 years

2025-09-15

Abstract excerpt

Mobile genetic elements (MGEs), including plasmids, phages and genome islands, are major sources of bacterial genetic diversity. The small plasmid pT181 confers tetracycline resistance in bacterial pathogen Staphylococcus aureus via an efflux pump, TetK. pT181 was one of the earliest sequenced S. aureus plasmids, and has been isolated in both clinical and livestock-associated strains for decades, both as an inde...

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Literature Corpus work
95ac3b16-4473-5822-b5df-6a005f56b750
DOI
10.1101/2025.09.14.675889
Open publication

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Transition of <i>Staphylococcus aureus</i> tetracycline resistance plasmid pT181 from independent multicopy replicon to predominantly integrated chromosomal element over 65 yearsDOI 10.1101/2025.09.14.675889
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