Article
Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.
Proceedings of the National Academy of Sciences of the United States of America - 29 Jun 2004
Holden Matthew T G, Feil Edward J, Lindsay Jodi A, Peacock Sharon J, Day Nicholas P J, Enright Mark C, Foster Tim J, Moore Catrin E, Hurst Laurence, Atkin Rebecca, Barron Andrew, Bason Nathalie, Bentley Stephen D, Chillingworth Carol, Chillingworth Tracey, Churcher Carol, Clark Louise, Corton Craig, Cronin Ann, Doggett Jon, Dowd Linda, Feltwell Theresa, Hance Zahra, Harris Barbara, Hauser Heidi, Holroyd Simon, Jagels Kay, James Keith D, Lennard Nicola, Line Alexandra, Mayes Rebecca, Moule Sharon, Mungall Karen, Ormond Douglas, Quail Michael A, Rabbinowitsch Ester, Rutherford Kim, Sanders Mandy, Sharp Sarah, Simmonds Mark, Stevens Kim, Whitehead Sally, Barrell Bart G, Spratt Brian G, Parkhill Julian
Abstract excerpt
Staphylococcus aureus is an important nosocomial and community-acquired pathogen. Its genetic plasticity has facilitated the evolution of many virulent and drug-resistant strains, presenting a major and constantly changing clinical challenge. We sequenced the approximately 2.8-Mbp genomes of two disease-causing S. aureus strains isolated from distinct clinical settings: a recent hospital-acquired representative...
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