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The Natural Carotenoid Crocetin and the Synthetic Tellurium Compound AS101 Protect the Ovary against Cyclophosphamide by Modulating SIRT1 and Mitochondrial Markers

1 Jan 2017

Abstract excerpt

Cancer therapies are associated with increased infertility risk due to accelerated reproductive aging. Oxidative stress (OS) is a potential mechanism behind ovarian toxicity by cyclophosphamide (CPM), the most ovotoxic anticancer drug. An important sensor of OS is SIRT1, a NAD+‐dependent deacetylase which regulates cellular defence and cell fate. This study investigated whether the natural carotenoid crocetin and...

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PMID: 29270246
DOI: 10.1155/2017/8928604

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