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Article

Double negative (CD19+IgG+IgD-CD27-) B lymphocytes: a new insight from telomerase in healthy elderly, in centenarian offspring and in Alzheimer's disease patients.

Immunology letters - 1 Nov 2014

Martorana Adriana, Balistreri Carmela Rita, Bulati Matteo, Buffa Silvio, Azzarello Delia Maria, Camarda Cecilia, Monastero Roberto, Caruso Calogero, Colonna-Romano Giuseppina

Abstract excerpt

Immunosenescence is characterized by the impairment of humoral immunity with changes in the memory/naive B cell compartment. In particular we have previously reported the percentage increase of a Memory IgD(-)CD27(-) (Double Negative, DN) B cell population in aged people. In this study, we have further characterized DN B cells with the aim to better understand their contribution to immunosenescence. As DN B cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24951896
DOI: 10.1016/j.imlet.2014.06.003

Genes

BCR
TLR9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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