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Article

B Cell Immunosenescence in the Elderly and in Centenarians

1 Apr 2008

Abstract excerpt

The elderly suffer from an increased susceptibility to infectious disease and cancer. Aging of the immune system contributes to this state of affairs due to immunosenescence. Because repeated intermittent or chronic antigen exposure may lead to lymphocyte clonal exhaustion, chronic antigenic stress plays a part in the compromised immunity of the elderly, who have accumulated a lifetime's exposure to infectious...

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PMID: 18442327
DOI: 10.1089/rej.2008.0664

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