Article
Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer.
Gut - 1 Apr 2015
Yu Jun, Wu William K K, Li Xiangchun, He Jun, Li Xiao-Xing, Ng Simon S M, Yu Chang, Gao Zhibo, Yang Jie, Li Miao, Wang Qiaoxiu, Liang Qiaoyi, Pan Yi, Tong Joanna H, To Ka F, Wong Nathalie, Zhang Ning, Chen Jie, Lu Youyong, Lai Paul B S, Chan Francis K L, Li Yingrui, Kung Hsiang-Fu, Yang Huanming, Wang Jun, Sung Joseph J Y
Abstract excerpt
BACKGROUND: Characterisation of colorectal cancer (CRC) genomes by next-generation sequencing has led to the discovery of novel recurrently mutated genes. Nevertheless, genomic data has not yet been used for CRC prognostication. OBJECTIVE: To identify recurrent somatic mutations with prognostic significance in patients with CRC. METHOD: Exome sequencing was performed to identify somatic mutations in tumour...
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