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Article

Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons.

Neuron - 18 Jun 2014

Ozkan Emin D, Creson Thomas K, Kramár Enikö A, Rojas Camilo, Seese Ron R, Babyan Alex H, Shi Yulin, Lucero Rocco, Xu Xiangmin, Noebels Jeffrey L, Miller Courtney A, Lynch Gary, Rumbaugh Gavin

Abstract excerpt

Syngap1 haploinsufficiency is a common cause of sporadic intellectual disability. Syngap1 mutations disrupt developing pyramidal neurons, although it remains unclear if this process contributes to cognitive abnormalities. Here, we found that haploinsufficiency restricted to forebrain glutamatergi...

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Identifiers

PMID: 24945774
DOI: 10.1016/j.neuron.2014.05.015
PMCID: PMC4104574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24945774-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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