Article
Tumor microenvironment and RIG-I signaling molecules in Epstein Barr virus-positive and -negative classical Hodgkin lymphoma of the elderly.
Journal of clinical and experimental hematopathology : JCEH - 1 Jan 2014
Satoh Tsugumi, Wada Ryuichi, Yajima Nobuhisa, Imaizumi Tadaatsu, Yagihashi Soroku
Abstract excerpt
Classical Hodgkin lymphoma (CHL) is a B-cell neoplasm characterized by Hodgkin and Reed-Sternberg (HRS) cells. Its prevalence exhibits a bimodal pattern of peaking in young adults and the elderly. There is an association with Epstein-Barr virus (EBV) infection in about 50% of cases of CHL of the elderly, and the outcome of these patients is unfavorable. It is not well known how the latent infection of EBV is...
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