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Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling

19 Jun 2014

Abstract excerpt

The G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here we show that CB2R and GPR55 form heteromers in cancer cells, that these structures possess unique signaling properties, and that modulation of...

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PMID: 24942731
DOI: 10.1074/jbc.m114.561761

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