Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cannabidiol reverts the malignant phenotype of hepatocellular carcinoma cells via the GPR55/TP53/MAPK axis.

Biochimica et biophysica acta. General subjects - 1 Aug 2024

Tan Shirui, Zaman Qamar Uz, Fahad Shah, Deng Gang

Abstract excerpt

Cannabidiol (CBD) has antioxidant and anti-inflammatory activities. However, the anti-tumor effect of CBD on hepatocellular carcinoma (HCC) remains unclear. Here, we investigated whether CBD displays anti-tumorigenic effects in HCC cells and whether it could reduce tumorigenesis and metastases in vivo. First, this study treated HCC cells with different concentrations of CBD, followed by analyzing the changes in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Movement

Share to Gene Expression Regulation, Neoplastic

Share to Liver Neoplasms

Share to MAP Kinase Signaling System

Share to Mice, Nude

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 38825256
DOI: 10.1016/j.bbagen.2024.130651

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cannabidiol reverts the malignant phenotype of hepatocellular carcinoma cells via the GPR55/TP53/MAPK axis.PMID 38825256Read ↗

Antitumor Effects of Cannabidiol (CBD) on Osteosarcoma by Targeting TNF-α/NF-κB/CCL5 Signaling AxisSemantic proximity Read ↗

The strengths and limits of cannabinoids and their receptors in cancer: Insights into the role of tumorigenesis-underlying mechanisms and therapeutic aspectsSemantic proximity Read ↗

Cannabidiol potentiates p53-driven autophagic cell death in non-small cell lung cancer following DNA damage: a novel synergistic approach beyond canonical pathwaysSemantic proximity Read ↗

Cannabinoid-associated cell death mechanisms in tumor modelsSemantic proximity Read ↗

Cannabigerol potentiates rivoceranib in hepatocellular carcinoma through a receptor-independent ER stress–calcium program that collapses the E2F1–FOXM1 axisSemantic proximity Read ↗

Evaluating the Antitumor Potential of Cannabichromene, Cannabigerol, and Related Compounds from Cannabis sativa and Piper nigrum Against Malignant Glioma: An In Silico to In Vitro ApproachSemantic proximity Read ↗

Cannabinoids, their cellular receptors, and effects on the invasive phenotype of carcinoma and metastasis.Semantic proximity Read ↗

CANNABIDIOL MODULATES CLASSICAL AND NON-CLASSICAL HLA EXPRESSION IN HUMAN CHORIOCARCINOMA CELL LINESemantic proximity Read ↗

Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer InterventionsSemantic proximity Read ↗

Use of Cannabis and Cannabinoids for Treatment of CancerSemantic proximity Read ↗

Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell SignalingSemantic proximity Read ↗

A Network Pharmacology Approach to Identify Potential Molecular Targets for Cannabidiol's Anti-Inflammatory ActivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.