Article
Patients benefit from genetics-guided coumarin anticoagulant therapy.
Clinical pharmacology and therapeutics - 1 Jul 2014
Maitland-van der Zee A H, Daly A K, Kamali F, Manolopoulous V G, Manolopoulos V G, Verhoef T I, Wadelius M, de Boer A, Pirmohamed M
Abstract excerpt
Observational studies have overwhelmingly shown that variants in the genes CYP2C9 and VKORC1 are significant determinants of individual dose of coumarin anticoagulants needed to maintain a therapeutic international normalized ratio (INR).(1) Until recently, however, few randomized clinical trials had been performed relating to the use of genetic data to predict dosing. Three sucsh clinical trials have now...
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