Article
Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
PloS one - 1 Jan 2014
Liang Yu, Tang Weizhong, Huang Tiqiang, Gao Yong, Tan Aihua, Yang Xiaobo, Zhang Haiying, Hu Yanling, Qin Xue, Li Shan, Zhang Shijun, Mo Linjian, Liang Zhenjia, Shi Deyi, Huang Zhang, Guan Yingyong, Zhou Jicheng, Winkler Cheryl, O'Brien Stephen J, Xu Jianfeng, Mo Zengnan, Peng Tao
Abstract excerpt
BACKGROUND: Serum carcinoembryonic antigen (sCEA) level might be an indicator of disease. Indeed, an elevated sCEA level is a prognostic factor in colorectal cancer (CRC) patients. However, the genetic determinants of sCEA level in healthy and CRC population remains unclear. Thus we investigated the genetic markers associated with elevated serum sCEA level in these two populations and its clinical implications....
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