Article
OccuPeak: ChIP-Seq peak calling based on internal background modelling.
PloS one - 1 Jan 2014
de Boer Bouke A, van Duijvenboden Karel, van den Boogaard Malou, Christoffels Vincent M, Barnett Phil, Ruijter Jan M
Abstract excerpt
UNLABELLED: ChIP-seq has become a major tool for the genome-wide identification of transcription factor binding or histone modification sites. Most peak-calling algorithms require input control datasets to model the occurrence of background reads to account for local sequencing and GC bias. However, the GC-content of reads in Input-seq datasets deviates significantly from that in ChIP-seq datasets. Moreover, we...
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