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Article

Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa.

eLife - 27 Aug 2013

Tucker Budd A, Mullins Robert F, Streb Luan M, Anfinson Kristin, Eyestone Mari E, Kaalberg Emily, Riker Megan J, Drack Arlene V, Braun Terry A, Stone Edwin M

Abstract excerpt

Next-generation and Sanger sequencing were combined to identify disease-causing USH2A mutations in an adult patient with autosomal recessive RP. Induced pluripotent stem cells (iPSCs), generated from the patient's keratinocytes, were differentiated into multi-layer eyecup-like structures with features of human retinal precursor cells. The inner layer of the eyecups contained photoreceptor precursor cells that...

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Source

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Identifiers

PMID: 23991284
DOI: 10.7554/eLife.00824
PMCID: PMC3755341

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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