Article
Pathway analysis of cervical cancer genome-wide association study highlights the MHC region and pathways involved in response to infection.
Human molecular genetics - 15 Nov 2014
Chen Dan, Enroth Stefan, Ivansson Emma, Gyllensten Ulf
Abstract excerpt
Cervical cancer is caused by infection with human papillomavirus (HPV). A genome-wide association study (GWAS) has identified several susceptibility loci for cervical cancer, but they explain only a small fraction of cervical cancer heritability. Other variants with weaker effect may be missed due to the stringent significance threshold. To identify important pathways in cervical carcinogenesis, we performed a...
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