CHRNA5 variants moderate the effect of nicotine deprivation on a neural index of cognitive control.

doi:10.1111/gbb.12151

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Article

CHRNA5 variants moderate the effect of nicotine deprivation on a neural index of cognitive control.

Genes, brain, and behavior - 1 Sept 2014

Evans D E, MacQueen D A, Jentink K G, Park J Y, Lin H-Y, Drobes D J

Abstract excerpt

Individuals with reduced attention and memory cognitive control-related processes may be motivated to smoke as a result of the cognitive enhancing effects of nicotine. Further, nicotine deprivation-induced reductions in cognitive control may negatively reinforce smoking. Minor allele carriers at rs16969968 in the nicotinic acetylcholine receptor α5 subunit gene (CHRNA5) have been shown to exhibit both reduced...

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PMID: 24934182
DOI: 10.1111/gbb.12151
PMCID: PMC4178975

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CHRNA5

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