Article
The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia.
Proceedings of the National Academy of Sciences of the United States of America - 10 Oct 2006
Dunfee Rebecca L, Thomas Elaine R, Gorry Paul R, Wang Jianbin, Taylor Joann, Kunstman Kevin, Wolinsky Steven M, Gabuzda Dana
Abstract excerpt
HIV infects tissue macrophages and brain microglia, which express lower levels of CD4 and CCR5 than CD4+ T cells in peripheral blood. Mechanisms that enhance HIV tropism for macrophages in the CNS and other tissues are not well understood. Here, we identify an HIV envelope glycoprotein (Env) variant in the CD4-binding site of gp120, Asn 283 (N283), that is present at a high frequency in brain tissues from AIDS...
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