Article
Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb.
Proceedings of the National Academy of Sciences of the United States of America - 17 Jun 2014
Mayeuf-Louchart Alicia, Lagha Mounia, Danckaert Anne, Rocancourt Didier, Relaix Frederic, Vincent Stéphane D, Buckingham Margaret
Abstract excerpt
Multipotent Pax3-positive (Pax3(+)) cells in the somites give rise to skeletal muscle and to cells of the vasculature. We had previously proposed that this cell-fate choice depends on the equilibrium between Pax3 and Foxc2 expression. In this study, we report that the Notch pathway promotes vascu...
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