Article
Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146.
PloS one - 1 Jan 2013
Then Cornelia, Wahl Simone, Kirchhofer Anna, Grallert Harald, Krug Susanne, Kastenmüller Gabi, Römisch-Margl Werner, Claussnitzer Melina, Illig Thomas, Heier Margit, Meisinger Christa, Adamski Jerzy, Thorand Barbara, Huth Cornelia, Peters Annette, Prehn Cornelia, Heukamp Ina, Laumen Helmut, Lechner Andreas, Hauner Hans, Seissler Jochen
Abstract excerpt
AIMS/HYPOTHESIS: Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene have been shown to display a powerful association with type 2 diabetes. The aim of the present study was to evaluate metabolic alterations in carriers of a common TCF7L2 risk variant. METHODS: Seventeen non-diabetic subjects carrying the T risk allele at the rs7903146 TCF7L2 locus and 24 subjects carrying no risk allele were...
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