Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations.

doi:10.1038/s41467-022-34475-3

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations.

Nature communications - 11 Nov 2022

Thorpe Harry A, Tourrette Elise, Yahara Koji, Vale Filipa F, Liu Siqi, Oleastro Mónica, Alarcon Teresa, Perets Tsachi-Tsadok, Latifi-Navid Saeid, Yamaoka Yoshio, Martinez-Gonzalez Beatriz, Karayiannis Ioannis, Karamitros Timokratis, Sgouras Dionyssios N, Elamin Wael, Pascoe Ben, Sheppard Samuel K, Ronkainen Jukka, Aro Pertti, Engstrand Lars, Agreus Lars, Suerbaum Sebastian, Thorell Kaisa, Falush Daniel

Abstract excerpt

Helicobacter pylori lives in the human stomach and has a population structure resembling that of its host. However, H. pylori from Europe and the Middle East trace substantially more ancestry from modern African populations than the humans that carry them. Here, we use a collection of Afro-Eurasian H. pylori genomes to show that this African ancestry is due to at least three distinct admixture events. H. pylori...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Africa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Black People

Share to Escherichia coli research studies

Share to Helicobacter Infections

Share to Helicobacter pylori

Share to Helicobacter pylori-related gastroenterology studies

Share to Mutation

Share to Viral gastroenteritis research and epidemiology

Source

Open in PubMed Open full text

Identifiers

PMID: 36369175
DOI: 10.1038/s41467-022-34475-3
PMCID: PMC9652371

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations.PMID 36369175Read ↗

Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutationsSemantic proximity Read ↗

An African origin for the intimate association between humans and Helicobacter pylori.Semantic proximity Read ↗

A 500-year tale of co-evolution, adaptation, and virulence: Helicobacter pylori in the Americas.Semantic proximity Read ↗

Helicobacter pylori Sequences Reflect Past Human Migrations.Semantic proximity Read ↗

Recent acquisition of Helicobacter pylori by Baka pygmies.Semantic proximity Read ↗

Genomic evolution and transmission of Helicobacter pylori in two South African familiesSemantic proximity Read ↗

Age of the association between Helicobacter pylori and man.Semantic proximity Read ↗

Evolutionary History of the Helicobacter pylori Genome: Implications for Gastric CarcinogenesisSemantic proximity Read ↗

Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweepsSemantic proximity Read ↗

Genomic variation and ancestry of Helicobacter pylori in the admixed population of Cabo Verde reveal host adaptation, limited host–pathogen ancestry concordance, and signatures of trans-Atlantic slave trade migrationsSemantic proximity Read ↗

Rapid evolution of distinct Helicobacter pylori subpopulations in the Americas.Semantic proximity Read ↗

Population genetic analyses of Helicobacter pylori isolates from Gambian adults and children.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.