Article
Microevolution of Helicobacter pylori during prolonged infection of single hosts and within families.
PLoS genetics - 22 Jul 2010
Morelli Giovanna, Didelot Xavier, Kusecek Barica, Schwarz Sandra, Bahlawane Christelle, Falush Daniel, Suerbaum Sebastian, Achtman Mark
Abstract excerpt
Our understanding of basic evolutionary processes in bacteria is still very limited. For example, multiple recent dating estimates are based on a universal inter-species molecular clock rate, but that rate was calibrated using estimates of geological dates that are no longer accepted. We therefore estimated the short-term rates of mutation and recombination in Helicobacter pylori by sequencing an average of...
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