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Progressive genomic convergence of two Helicobacter pylori strains during mixed infection of a patient with chronic gastritis

9 Jul 2014

Abstract excerpt

OBJECTIVE: To study the detailed nature of genomic microevolution during mixed infection with multiple Helicobacter pylori strains in an individual. DESIGN: We sampled 18 isolates from a single biopsy from a patient with chronic gastritis and nephritis. Whole-genome sequencing was applied to these isolates, and statistical genetic tools were used to investigate their evolutionary history. RESULTS: The genomes...

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PMID: 25007814
DOI: 10.1136/gutjnl-2014-307345

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