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Differentiation of human umbilical cord mesenchymal stem cells into germ-like cells in mouse seminiferous tubules

23 Mar 2015

Abstract excerpt

Our previous study demonstrated that human umbilical cord mesenchymal stem cells (HUMSCs) were capable of differentiation into germ cells in vitro. To assess this potential in vivo, HUMSCs were microinjected into the lumen of seminiferous tubules of immunocompetent mice, which were treated with busulfan to destroy endogenous spermatogenesis. Bromodeoxyuridine labeling studies demonstrated that HUMSCs survived in...

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PMID: 25815600
DOI: 10.3892/mmr.2015.3528

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