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PARK7 protein translocating into spermatozoa mitochondria in Chinese asthenozoospermia

12 Jun 2014

Abstract excerpt

PARK7 (DJ1) is a multifunctional oxidative stress response protein that protects cells against reactive oxygen species (ROS) and mitochondrial damage. PARK7 defects are known to cause various physiological dysfunctions, including infertility. Asthenozoospermia (AS), i.e. low-motile spermatozoa in the ejaculate, is a common cause of human male infertility. In this study, we found that downregulation of PARK7...

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PMID: 24920663
DOI: 10.1530/rep-14-0222

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