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Activation of autophagy is required for clearance of mitochondrial ROS in patients with asthenozoospermia

13 Feb 2025

Abstract excerpt

Autophagy is regarded as an essential process for maintaining cell homeostasis. However, its role in the regulation of sperm motility is still less understood. In this study, we found that mitochondrial oxidative species (mROS) levels were elevated, but ATP levels and mitochondrial membrane potential (MMP) levels were reduced in human sperm with low motility (also called asthenozoospermia, AS) as compared to...

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PMID: 39959826
DOI: 10.7717/peerj.18827

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