Article
Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach.
European journal of human genetics : EJHG - 1 Mar 2015
Versmissen Jorie, Oosterveer Daniëlla M, Yazdanpanah Mojgan, Dehghan Abbas, Hólm Hilma, Erdman Jeanette, Aulchenko Yurii S, Thorleifsson Gudmar, Schunkert Heribert, Huijgen Roeland, Vongpromek Ranitha, Uitterlinden André G, Defesche Joep C, van Duijn Cornelia M, Mulder Monique, Dadd Tony, Karlsson Hróbjartur D, Ordovas Jose, Kindt Iris, Jarman Amelia, Hofman Albert, van Vark-van der Zee Leonie, Blommesteijn-Touw Adriana C, Kwekkeboom Jaap, Liem Anho H, van der Ouderaa Frans J, Calandra Sebastiano, Bertolini Stefano, Averna Maurizio, Langslet Gisle, Ose Leiv, Ros Emilio, Almagro Fátima, de Leeuw Peter W, Civeira Fernando, Masana Luis, Pintó Xavier, Simoons Maarten L, Schinkel Arend F L, Green Martin R, Zwinderman Aeilko H, Johnson Keith J, Schaefer Arne, Neil Andrew, Witteman Jacqueline C M, Humphries Steve E, Kastelein John J P, Sijbrands Eric J G
Abstract excerpt
Mutations in the low-density lipoprotein receptor (LDLR) gene cause familial hypercholesterolemia (FH), a disorder characterized by coronary heart disease (CHD) at young age. We aimed to apply an extreme sampling method to enhance the statistical power to identify novel genetic risk variants for...
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