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Article

A cisplatin-resistant head and neck cancer cell line with cytoplasmic p53(mut) exhibits ATP-binding cassette transporter upregulation and high glutathione levels.

Journal of cancer research and clinical oncology - 1 Oct 2014

Tonigold Manuel, Rossmann Annette, Meinold Marie, Bette Michael, Märken Melanie, Henkenius Katharina, Bretz Anne C, Giel Gavin, Cai Chengzhong, Rodepeter Fiona R, Beneš Vladimir, Grénman Reidar, Carey Thomas E, Lage Hermann, Stiewe Thorsten, Neubauer Andreas, Werner Jochen A, Brendel Cornelia, Mandic Robert

Abstract excerpt

PURPOSE: Head and neck squamous cell carcinoma (HNSCC) cell lines with cytoplasmically sequestered mutant p53 (p53(mut_c)) are frequently more resistant to cisplatin (CDDP) than cells with mutant but nuclear p53 (p53(mut_n)). The aim of the study was to identify underlying mechanisms implicated i...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Identifiers

PMID: 24913304
DOI: 10.1007/s00432-014-1727-y

Genes

ABCC2
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-24913304-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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