Article
B cells regulate macrophage phenotype and response to chemotherapy in squamous carcinomas.
Cancer cell - 16 Jun 2014
Affara Nesrine I, Ruffell Brian, Medler Terry R, Gunderson Andrew J, Johansson Magnus, Bornstein Sophia, Bergsland Emily, Steinhoff Martin, Li Yijin, Gong Qian, Ma Yan, Wiesen Jane F, Wong Melissa H, Kulesz-Martin Molly, Irving Bryan, Coussens Lisa M
Abstract excerpt
B cells foster squamous cell carcinoma (SCC) development through deposition of immunoglobulin-containing immune complexes in premalignant tissue and Fcγ receptor-dependent activation of myeloid cells. Because human SCCs of the vulva and head and neck exhibited hallmarks of B cell infiltration, we examined B cell-deficient mice and found reduced support for SCC growth. Although ineffective as a single agent,...
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