miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110.

doi:10.1038/nature13413

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Article

miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110.

Nature - 5 Jun 2014

Song Rui, Walentek Peter, Sponer Nicole, Klimke Alexander, Lee Joon Sub, Dixon Gary, Harland Richard, Wan Ying, Lishko Polina, Lize Muriel, Kessel Michael, He Lin

Abstract excerpt

The mir-34/449 family consists of six homologous miRNAs at three genomic loci. Redundancy of miR-34/449 miRNAs and their dominant expression in multiciliated epithelia suggest a functional significance in ciliogenesis. Here we report that mice deficient for all miR-34/449 miRNAs exhibited postnatal mortality, infertility and strong respiratory dysfunction caused by defective mucociliary clearance. In both mouse...

Topics

Animals
Animals, Newborn
Basal Bodies
Base Sequence
Calmodulin-Binding Proteins
Centrioles
Cilia
Epidermis
Female
Infertility
Kartagener Syndrome
Male
Mice
Mice, Knockout

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MicroRNAs

Morphogenesis

Phenotype

Respiratory System

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Identifiers

PMID: 24899310
DOI: 10.1038/nature13413
PMCID: PMC4119886

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