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Article

Polymorphism in PHD1 gene and risk of non-small cell lung cancer in a Chinese population.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Sept 2014

Che Jianhua, Jiang Dong, Zheng Yabiao, Zhu Bin, Zhang Ping, Lu Deyi, Zhang Junjie, Xiao Juanjuan, Wang Jianguo, Gao Yuzhen, Yan Xiaolong, Wang Minghua

Abstract excerpt

Hypoxia is a common phenomenon in the development of solid tumors, and hypoxia inducible factor 1 (HIF-1) plays a central role in coordinating the cellular response to hypoxia and in oxygen homeostasis. The prolyl hydrolase 1 (PHD1) is a key adjustment factor that mediates the HIF-1 degradation and relates with the process of tumorigenesis. Thus, polymorphism in PHD1 may affect cellular response to hypoxic...

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PMID: 24894671
DOI: 10.1007/s13277-014-2112-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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