Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer.

doi:10.1371/journal.pone.0096767

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Article

Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer.

PloS one - 1 Jan 2014

Christensen Lise Lotte, Holm Anja, Rantala Juha, Kallioniemi Olli, Rasmussen Mads H, Ostenfeld Marie S, Dagnaes-Hansen Frederik, Øster Bodil, Schepeler Troels, Tobiasen Heidi, Thorsen Kasper, Sieber Oliver M, Gibbs Peter, Lamy Philippe, Hansen Torben F, Jakobsen Anders, Riising Eva M, Helin Kristian, Lubinski Jan, Hagemann-Madsen Rikke, Laurberg Søren, Ørntoft Torben F, Andersen Claus L

Abstract excerpt

MicroRNAs (miRNAs) play a critical role in many biological processes and are aberrantly expressed in human cancers. Particular miRNAs function either as tumor suppressors or oncogenes and appear to have diagnostic and prognostic significance. Although numerous miRNAs are dys-regulated in colorectal cancer (CRC) only a small fraction has been characterized functionally. Using high-throughput functional screening...

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Identifiers

PMID: 24892549
DOI: 10.1371/journal.pone.0096767
PMCID: PMC4043686

Genes

YAP1
HELLS
MKI67
NOLC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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