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Article

KRLMM: an adaptive genotype calling method for common and low frequency variants.

BMC bioinformatics - 23 May 2014

Liu Ruijie, Dai Zhiyin, Yeager Meredith, Irizarry Rafael A, Ritchie Matthew E

Abstract excerpt

BACKGROUND: SNP genotyping microarrays have revolutionized the study of complex disease. The current range of commercially available genotyping products contain extensive catalogues of low frequency and rare variants. Existing SNP calling algorithms have difficulty dealing with these low frequency variants, as the underlying models rely on each genotype having a reasonable number of observations to ensure...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24886250
DOI: 10.1186/1471-2105-15-158
PMCID: PMC4064501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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