Article
Prospective signs of cleidocranial dysplasia in Cebpb deficiency.
Journal of biomedical science - 13 May 2014
Huang Boyen, Takahashi Katsu, Jennings Ernest A, Pumtang-On Pongthorn, Kiso Honoka, Togo Yumiko, Saito Kazuyuki, Sugai Manabu, Akira Shizuo, Shimizu Akira, Bessho Kazuhisa
Abstract excerpt
BACKGROUND: Although runt-related transcription factor 2 (RUNX2) has been considered a determinant of cleidocranial dysplasia (CCD), some CCD patients were free of RUNX2 mutations. CCAAT/enhancer-binding protein beta (Cebpb) is a key factor of Runx2 expression and our previous study has reported two CCD signs including hyperdontia and elongated coronoid process of the mandible in Cebpb deficient mice. Following...
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