Article
RUNX2 mutations in cleidocranial dysplasia patients.
Oral diseases - 1 Jan 2010
Ryoo H-M, Kang H-Y, Lee S-K, Lee K-E, Kim J-W
Abstract excerpt
OBJECTIVE: Mutations in the RUNX2 gene, a master regulator of bone formation, have been identified in cleidocranial dysplasia (CCD) patients. CCD is a rare autosomal-dominant disease characterized by the delayed closure of cranial sutures, defects in clavicle formation, and supernumerary teeth. The purposes of this study were to identify genetic causes of two CCD nuclear families and to report their clinical...
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