Granzyme B gene polymorphism associated with subacute sclerosing panencephalitis.

doi:10.1055/s-0034-1378129

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Article

Granzyme B gene polymorphism associated with subacute sclerosing panencephalitis.

Neuropediatrics - 1 Oct 2014

Yentur Sibel P, Aydin Hatice Nur, Gurses Candan, Demirbilek Veysi, Kuru Umit, Uysal Serap, Yapici Zuhal, Baris Safa, Yilmaz Gülden, Cokar Ozlem, Onal Emel, Gokyigit Ayşen, Saruhan-Direskeneli Güher

Abstract excerpt

BACKGROUND: Subacute sclerosing panencephalitis (SSPE) is a late complication of measles infection. Immune dysfunction related to genetic susceptibility has been considered in disease pathogenesis. A functional single nucleotide polymorphism (SNP) of granzyme B gene (GZMB) reported in several pathologies may also be involved in susceptibility to SSPE. PATIENTS AND METHODS: An SNP (rs8192917, G → A, R→Q) was...

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PMID: 24875585
DOI: 10.1055/s-0034-1378129

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GZMB

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