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Article

SPIB and BATF provide alternate determinants of IRF4 occupancy in diffuse large B-cell lymphoma linked to disease heterogeneity.

Nucleic acids research - 1 Jul 2014

Care Matthew A, Cocco Mario, Laye Jon P, Barnes Nicholas, Huang Yuanxue, Wang Ming, Barrans Sharon, Du Ming, Jack Andrew, Westhead David R, Doody Gina M, Tooze Reuben M

Abstract excerpt

Interferon regulatory factor 4 (IRF4) is central to the transcriptional network of activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL), an aggressive lymphoma subgroup defined by gene expression profiling. Since cofactor association modifies transcriptional regulatory input by IRF4, we assessed genome occupancy by IRF4 and endogenous cofactors in ABC-DLBCL cell lines. IRF4 partners with SPIB, PU.1 and...

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Topics

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Share to B-Lymphocytes
Share to Basic-Leucine Zipper Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon Regulatory Factors

Share to Lymphoma, Large B-Cell, Diffuse

Share to Myeloid Differentiation Factor 88

Share to Nucleotide Motifs

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Source

Open in PubMed Open full text

Identifiers

PMID: 24875472
DOI: 10.1093/nar/gku451
PMCID: PMC4081075

Genes

SPIB
BATF
MYD88

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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