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Article

Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways

2 Sept 2008

Abstract excerpt

Gene-expression profiling has been used to define 3 molecular subtypes of diffuse large B-cell lymphoma (DLBCL), termed germinal center B-cell-like (GCB) DLBCL, activated B-cell-like (ABC) DLBCL, and primary mediastinal B-cell lymphoma (PMBL). To investigate whether these DLBCL subtypes arise by distinct pathogenetic mechanisms, we analyzed 203 DLBCL biopsy samples by high-resolution, genome-wide copy number...

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PMID: 18765795
DOI: 10.1073/pnas.0804295105

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