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Article

NEXN inhibits GATA4 and leads to atrial septal defects in mice and humans.

Cardiovascular research - 15 Jul 2014

Yang Fan, Zhou Lei, Wang Qiguang, You Xin, Li Ying, Zhao Yong, Han Xiaonan, Chang Zai, He Xin, Cheng Chunyan, Wu Chong, Wang Wen-Jing, Hu Fang-Yuan, Zhao Ting, Li Yang, Zhao Ming, Zheng Gu-Yan, Dong Jie, Fan Chun, Yang Juxian, Meng Xianmin, Zhang Youyi, Zhu Xianyang, Xiong Jingwei, Tian Xiao-Li, Cao Huiqing

Abstract excerpt

AIMS: Cardiac structural genes have been implicated as causative factors for congenital heart diseases (CHDs). NEXN is an F-actin binding protein and previously identified as a disease gene causing cardiomyopathies. Whether NEXN contributes to CHDs aetiologically remains unknown. Here, we explored the function of NEXN in cardiac development. METHODS AND RESULTS: First, we determine the role of NEXN in cardiac...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24866383
DOI: 10.1093/cvr/cvu134
PMCID: PMC4498134

Genes

NEXN
GATA4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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