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Article

HYDIN loss-of-function inhibits GATA4 expression and enhances atrial septal defect risk.

Mechanisms of development - 1 Jun 2020

Cao Yu, Guo Junying, Zhang Jinping, Li Li, Wang Hui, Ren Wenjun, Jiang Lihong

Abstract excerpt

BACKGROUND: Mutations affecting cardiac structural genes can lead to congenital heart diseases (CHDs). Axonemal Central Pair Apparatus Protein (HYDIN) is a ciliary protein previously linked to congenital cardiomyopathy. However, the role of HYDIN in the aetiology of CHDs is thus far unknown. Herein, we explore the function of HYDIN in heart development and CHDs. METHODS: The function of HYDIN in cardiac...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 32376282
DOI: 10.1016/j.mod.2020.103611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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